NMFOffset-class. NMF 0.22

Description

This class implements the Nonnegative Matrix Factorization with Offset model, required by the NMF with Offset algorithm.

Usage

S4 (NMFOffset)
`initialize`(.Object, ..., offset)

Arguments

offset: optional numeric vector used to initialise slot ‘offset’.
.Object: An object: see the Details section.
...: data to include in the new object. Named arguments correspond to slots in the class definition. Unnamed arguments must be objects from classes that this class extends.

Details

The NMF with Offset algorithm is defined by Badea (2008) as a modification of the euclidean based NMF algorithm from Lee2001 (see section Details and references below). It aims at obtaining 'cleaner' factor matrices, by the introduction of an offset matrix, explicitly modelling a feature specific baseline -- constant across samples.

Methods

fittedsignature(object = "NMFOffset"): Computes the target matrix estimate for an NMFOffset object.

The estimate is computed as:
```
 W H + offset 
  
      
```
offsetsignature(object = "NMFOffset"): The function offset returns the offset vector from an NMF model that has an offset, e.g. an NMFOffset model.
rnmfsignature(x = "NMFOffset", target = "numeric"): Generates a random NMF model with offset, from class NMFOffset.

The offset values are drawn from a uniform distribution between 0 and the maximum entry of the basis and coefficient matrices, which are drawn by the next suitable rnmf method, which is the workhorse method rnmf,NMF,numeric.
showsignature(object = "NMFOffset"): Show method for objects of class NMFOffset

Creating objects from the Class

Object of class NMFOffset can be created using the standard way with operator new

However, as for all NMF model classes -- that extend class NMF-class, objects of class NMFOffset should be created using factory method nmfModel :

new('NMFOffset')

nmfModel(model='NMFOffset')

nmfModel(model='NMFOffset', W=w, offset=rep(1, nrow(w)))

See nmfModel for more details on how to use the factory method.

Initialize method

The initialize method for NMFOffset objects tries to correct the initial value passed for slot offset, so that it is consistent with the dimensions of the NMF model: it will pad the offset vector with NA values to get the length equal to the number of rows in the basis matrix.

References

Badea L (2008). "Extracting gene expression profiles common to colon and pancreatic adenocarcinoma using simultaneous nonnegative matrix factorization." _Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing_, *290*, pp. 267-78. ISSN 1793-5091, .

Examples



# create a completely empty NMF object
new('NMFOffset')

## <Object of class:NMFOffset>
## features: 0 
## basis/rank: 0 
## samples: 0 
## offset: none

# create a NMF object based on random (compatible) matrices
n <- 50; r <- 3; p <- 20
w <- rmatrix(n, r)
h <- rmatrix(r, p)
nmfModel(model='NMFOffset', W=w, H=h, offset=rep(0.5, nrow(w)))

## <Object of class:NMFOffset>
## features: 50 
## basis/rank: 3 
## samples: 20 
## offset: none

# apply Nonsmooth NMF algorithm to a random target matrix
V <- rmatrix(n, p)
## Not run: nmf(V, r, 'offset')

# random NMF model with offset
rnmf(3, 10, 5, model='NMFOffset')

## <Object of class:NMFOffset>
## features: 10 
## basis/rank: 3 
## samples: 5 
## offset: [ 0.2617822 0.5703196 0.5638419 0.1592346 0.5908754 ... ]

NMF Model - Nonnegative Matrix Factorization with Offset